New Generation Weight Loss Drugs: Safe Alternative to Ozempic, Inspired by Brain Biochemistry

11.08.2025 | Science and discoveries

Scientists have created the TDN molecule – a revolutionary anti-obesity drug that affects brain glial cells without typical side effects. Read how this discovery could change the battle with excess weight in Bulgaria.

Снимка от HualinXMN, Wikimedia Commons (CC BY-SA 4.0)

New Generation Weight Loss Drugs: Safe Alternative to Ozempic, Inspired by Brain Biochemistry

The Problem of Obesity and Limitations of Traditional Medications

Excess weight affects more and more Bulgarians, and the intake of drugs like Ozempic is gaining momentum. However, up to 70% of patients discontinue treatment due to side effects – nausea, vomiting, loss of appetite, and general discomfort.

Revolutionary Discovery: TDN – A New Approach Through Glial Cells

An international team of scientists created the TDN molecule, a special peptide that differs in its mode of action. Instead of directly affecting neurons, TDN activates glial cells (astrocytes) – a key mechanism in appetite control and metabolism. Through this approach, the drug reduces food cravings and stimulates fat breakdown without activating the chain causing unpleasant reactions like nausea.

Results in Laboratory Animals

Opportunities for Bulgaria and the Healthcare System

If TDN is approved after human clinical trials, Bulgarian society could gain access to a safer and more effective alternative in the fight against obesity. This would reduce the risk of chronic diseases such as diabetes and cardiovascular problems, improve quality of life, and limit medical expenses for the state.

Perspectives and Conclusion

The new generation of drugs, inspired by brain biochemistry and glial cells, promise a real revolution in obesity treatment. TDN could provide a solution without the social and health risks of current therapies – a new hope for thousands of Bulgarians who daily struggle with excess weight.